Science and techno world topic: Genetics
Father and child: Long caps in the genome |
Late paternity may extend the life of the young - scientists
come to this conclusion after comparing genetic strands. Old fathers pass
on to their children, therefore protective caps in the genes.
Washington - men who are late father bequeath to their
children and grandchildren long "caps" at the ends of chromosomes. A
shortening of telomeres is usually associated with aging processes in
combination. It is possible that the long caps in the offspring of older
fathers had a positive impact on their health or even their survival. Researchers
come to this conjecture in the scientific journal "PNAS" according
to the analysis of genome sequences, called telomeres.
Telomeres are repetitive DNA sequences at the ends of
chromosomes. In almost all cells, telomeres shorten with each cell
division a little. The older a person, the shorter the telomeres are
therefore usually its chromosomes. The shortening of these protective caps
too strong, there is no cell division takes longer. In an earlier study,
researchers found that older people with above-average short telomeres and a
shorter life expectancy.
When the sperm cells, the situation is different: in their
chromosomes, the telomeres with increasing age of the men getting longer.
Presumably this is due to a particularly high activity in the testis of the
telomerase enzyme - this is responsible for the construction of the telomeres.
The researchers led by Dan Eisenberg of Northwestern
University (Evanston / U.S. state of Illinois) is now being investigated in a
large, mixed-age group in the Philippines, whether the telomere length of the
Father, the telomere length in children and grandchildren affected.
To determine the length of telomeres in their body cells,
the researchers extracted the blood test subjects. It was found that
telomere length in the children actually had to do with the age of the father
at birth. Moreover, such children had never even longer telomeres, whose
paternal grandfathers were late become a father. That is, the age of
grandfathers - and thus the greater telomere length - had an impact not only on
the children, but also on the grandchildren. Over two generations, the
effect even added.
Each year, the fathers had later received a child who grew
the telomeres, the researchers report.
Whether the extended caps actually affect favorably the
health and life expectancy of the children and grandchildren, should be further
investigated. The scientists speculate, however, that the extension of
telomeres in societies with low mortality and more late reproduction increases
the life expectancy of offspring.
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